Article
GBA1-associated parkinsonism: new insights and therapeutic opportunities
12 Jun 2019
Abstract excerpt
PURPOSE OF REVIEW: GBA1 mutations, which result in the lysosomal disorder Gaucher disease, are the most common known genetic risk factor for Parkinson disease and Dementia with Lewy Bodies (DLB). The pathogenesis of this association is not fully understood, but further elucidation of this link could lead to new therapeutic options. RECENT FINDINGS: The characteristic clinical phenotype of GBA1-PD resembles...