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Microcephaly-Associated Genes <i>asp</i> and <i>Sas4</i> Control Chromatin Organization and Nuclear Lamina Structure in <i>Drosophila melanogaster</i>

2025-07-25

Abstract excerpt

<h4>ABSTRACT</h4> Autosomal recessive primary microcephaly (MCPH) is a neurodevelopmental disorder characterized by reduced brain size and non-progressive intellectual disability. Mutations in over 30 genes have been linked to MCPH. Nearly a half of the genes identified by these mutations encode proteins involved in centrosome biogenesis or microtubule (MT) dynamics, suggesting a central role for mitotic spindle...

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Literature Corpus work
6a0d21fb-ec37-57a5-a414-33123f06ce1d
DOI
10.1101/2025.07.22.666102
Open publication

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Microcephaly-Associated Genes <i>asp</i> and <i>Sas4</i> Control Chromatin Organization and Nuclear Lamina Structure in <i>Drosophila melanogaster</i>DOI 10.1101/2025.07.22.666102
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