Article
Deficient adaptation to centrosome duplication defects in neural progenitors causes microcephaly and subcortical heterotopias.
JCI insight - 23 Aug 2021
González-Martínez José, Cwetsch Andrzej W, Martínez-Alonso Diego, López-Sainz Luis R, Almagro Jorge, Melati Anna, Gómez Jesús, Pérez-Martínez Manuel, Megías Diego, Boskovic Jasminka, Gilabert-Juan Javier, Graña-Castro Osvaldo, Pierani Alessandra, Behrens Axel, Ortega Sagrario, Malumbres Marcos
Abstract excerpt
Congenital microcephaly (MCPH) is a neurodevelopmental disease associated with mutations in genes encoding proteins involved in centrosomal and chromosomal dynamics during mitosis. Detailed MCPH pathogenesis at the cellular level is still elusive, given the diversity of MCPH genes and lack of comparative in vivo studies. By generating a series of CRISPR/Cas9-mediated genetic KOs, we report here that - whereas...
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