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Article

The abnormal spindle-like, microcephaly-associated (ASPM) gene encodes a centrosomal protein.

Cell cycle (Georgetown, Tex.) - 1 Sept 2005

Zhong Xueyan, Liu Limin, Zhao Ailian, Pfeifer Gerd P, Xu Xingzhi

Abstract excerpt

Homozygous mutations in the abnormal spindle-like, microcephaly-associated ASPM gene are the leading cause of autosomal recessive primary microcephaly. ASPM is the putative human ortholog of the Drosophila melanogaster abnormal spindles gene (asp), which is essential for mitotic spindle function. Here, we report that downregulation of endogenous ASPM by siRNA decreases protein levels of endogenous BRCA1. ASPM...

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Share to BRCA1 Protein
Share to Centrosome
Share to Fluorescent Antibody Technique, Indirect

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16123590
DOI: 10.4161/cc.4.9.2029

Genes

ASPM
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The abnormal spindle-like, microcephaly-associated (ASPM) gene encodes a centrosomal protein.PMID 16123590Read ↗

Human microcephaly ASPM protein is a spindle pole-focusing factor that functions redundantly with CDK5RAP2Semantic proximity Read ↗

Human ASPM participates in spindle organisation, spindle orientation and cytokinesis.Semantic proximity Read ↗

Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline.Semantic proximity Read ↗

The microcephaly protein Abnormal Spindle has an essential role in symmetrically dividing neural precursors to promote brain growth and developmentSemantic proximity Read ↗

Microcephaly-associated genes asp and Sas4 influence chromatin organization and nuclear lamina structure in Drosophila melanogaster.Semantic proximity Read ↗

An Asp-CaM complex is required for centrosome-pole cohesion and centrosome inheritance in neural stem cells.Semantic proximity Read ↗

Autosomal recessive primary microcephaly due to ASPM mutations: An update.Semantic proximity Read ↗

Oncogenic ASPM Is a Regulatory Hub of Developmental and Stemness Signaling in CancersSemantic proximity Read ↗

Microcephaly-Associated Genes <i>asp</i> and <i>Sas4</i> Control Chromatin Organization and Nuclear Lamina Structure in <i>Drosophila melanogaster</i>Semantic proximity Read ↗

Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex.Semantic proximity Read ↗

Microcephaly protein Asp focuses the minus ends of spindle microtubules at the pole and within the spindle.Semantic proximity Read ↗

The neurodevelopmental transcriptome of the <i>Drosophila melanogaster</i> microcephaly gene <i>abnormal spindle</i> reveals a role for temporal transcription factors and the immune system in regulating brain sizeSemantic proximity Read ↗

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