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Article

The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the early embryo.

Journal of cell science - 15 Oct 2007

Rickmyre Jamie L, Dasgupta Shamik, Ooi Danny Liang-Yee, Keel Jessica, Lee Ethan, Kirschner Marc W, Waddell Scott, Lee Laura A

Abstract excerpt

Mutation of human microcephalin (MCPH1) causes autosomal recessive primary microcephaly, a developmental disorder characterized by reduced brain size. We identified mcph1, the Drosophila homolog of MCPH1, in a genetic screen for regulators of S-M cycles in the early embryo. Embryos of null mcph1...

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Identifiers

PMID: 17895362
DOI: 10.1242/jcs.016626

Genes

MCPH1
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17895362-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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