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The neurodevelopmental transcriptome of the <i>Drosophila melanogaster</i> microcephaly gene <i>abnormal spindle</i> reveals a role for temporal transcription factors and the immune system in regulating brain size

2023-01-10

Abstract excerpt

<h4>ABSTRACT</h4> The coordination of cellular behaviors during neurodevelopment is critical for determining the form, function, and size of the central nervous system. Mutations in the vertebrate Abnormal Spindle-Like, Microcephaly Associated (ASPM) gene and its Drosophila melanogaster ortholog abnormal spindle (asp) lead to microcephaly, a reduction in overall brain size whose etiology remains poorly defined...

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Literature Corpus work
d2d33a4c-165f-5080-a437-1981813da70f
DOI
10.1101/2023.01.09.523369
Open publication

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The neurodevelopmental transcriptome of the <i>Drosophila melanogaster</i> microcephaly gene <i>abnormal spindle</i> reveals a role for temporal transcription factors and the immune system in regulating brain sizeDOI 10.1101/2023.01.09.523369
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