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Article

Microcephaly-associated genes asp and Sas4 influence chromatin organization and nuclear lamina structure in Drosophila melanogaster.

Development (Cambridge, England) - 15 May 2026

Mengistu Degisew Yinur, Marzullo Marta, Pellacani Claudia, Marchetti Marcella, Terribili Marta, Montivero Morales Emma, Somma Maria Patrizia, Ciapponi Laura

Abstract excerpt

Autosomal recessive primary microcephaly (MCPH) is a neurodevelopmental disorder characterized by reduced brain size and intellectual disability. Mutations in over 30 genes, nearly half linked to centrosome biogenesis or microtubule (MT) dynamics, highlight spindle defects in disease aetiology, yet these alone do not fully explain MCPH. Here, we show that the Drosophila orthologs of ASPM/MCPH5 (asp) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42063344
DOI: 10.1242/dev.205125
PMCID: PMC13286369

Genes

ASPM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Microcephaly-associated genes asp and Sas4 influence chromatin organization and nuclear lamina structure in Drosophila melanogaster.PMID 42063344Read ↗

Microcephaly-Associated Genes <i>asp</i> and <i>Sas4</i> Control Chromatin Organization and Nuclear Lamina Structure in <i>Drosophila melanogaster</i>Semantic proximity Read ↗

Deficient adaptation to centrosome duplication defects in neural progenitors causes microcephaly and subcortical heterotopias.Semantic proximity Read ↗

Autosomal Recessive Primary Microcephaly (MCPH): clinical manifestations, genetic heterogeneity and mutation continuum.Semantic proximity Read ↗

Molecular genetics of human primary microcephaly: an overview.Semantic proximity Read ↗

Human microcephaly ASPM protein is a spindle pole-focusing factor that functions redundantly with CDK5RAP2Semantic proximity Read ↗

Dissecting the Genetic and Etiological Causes of Primary MicrocephalySemantic proximity Read ↗

The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the early embryo.Semantic proximity Read ↗

Human ASPM participates in spindle organisation, spindle orientation and cytokinesis.Semantic proximity Read ↗

Multifaceted Microcephaly-Related Gene MCPH1.Semantic proximity Read ↗

The abnormal spindle-like, microcephaly-associated (ASPM) gene encodes a centrosomal protein.Semantic proximity Read ↗

The microcephaly protein Abnormal Spindle has an essential role in symmetrically dividing neural precursors to promote brain growth and developmentSemantic proximity Read ↗

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