Article

Mbd4 and MutSα protect cells from spontaneous deamination of 5-methylcytosine

2024-12-18

Abstract excerpt

5-Methylcytosine (5mC) is a common source of somatic mutations. Deamination of 5mC to thymine generates a G/T mismatch, which occurs spontaneously and must be repaired prior to DNA replication to avoid mutation. We generated genetically engineered mice and cell lines to define DNA repair pathways that protect against methylation damage. We observed a low background mutation rate in mouse bone marrow or colon, typi...

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Literature Corpus work: 6a0c5d0e-cfe2-580b-a091-3a00adcd829e
DOI: 10.1101/2024.12.17.628571

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