Article

Human PMS1-dependent non-canonical mismatch repair converges with MBD4 to repair 5-methylcytosine deamination

2026-01-17

Abstract excerpt

CpG dinucleotides are hotspots for mutagenesis by spontaneous deamination of 5-methylcytosine (5mC) into thymine, resulting in T:G mismatches that can lead to C>T transitions. These mutations are a hallmark of aging and cancer and a major force shaping the evolution of vertebrate genomes. We have previously uncovered MBD4 as the primary base excision repair (BER) glycosylase responsible for 5mC deamination repair....

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Literature Corpus work: fa081a25-2cbc-5d94-bd13-c32807199270
DOI: 10.64898/2026.01.16.698129

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