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Article

Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice.

Science (New York, N.Y.) - 19 Jul 2002

Millar Catherine B, Guy Jacky, Sansom Owen J, Selfridge Jim, MacDougall Eilidh, Hendrich Brian, Keightley Peter D, Bishop Stefan M, Clarke Alan R, Bird Adrian

Abstract excerpt

The mammalian protein MBD4 contains a methyl-CpG binding domain and can enzymatically remove thymine (T) or uracil (U) from a mismatched CpG site in vitro. These properties suggest that MBD4 might function in vivo to minimize the mutability of 5-methylcytosine by removing its deamination product from DNA. We tested this hypothesis by analyzing Mbd4-/- mice and found that the frequency of of C --> T transitions at...

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Share to 5-Methylcytosine
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12130785
DOI: 10.1126/science.1073354

Genes

MBD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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