Article

Oxidative Stress Accelerates Repeat Instability and Base Substitutions, Promoting Gastrointestinal Driver Mutations under MSH2 Deficiency

2025-08-25

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Loss of DNA mismatch repair (MMR) increases mutagenesis and tumorigenesis. mutS homolog 2 (MSH2), a central component of the MMR pathway, is essential for correcting base-base mismatches and insertion/deletion loops during DNA replication. To investigate how <italic>Msh2</italic> deficiency cooperates with oxidative stress to drive mutagenesis and tumorigen...

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Literature Corpus work: 640b56f2-8cf9-52eb-9de9-330be1a68083
DOI: 10.21203/rs.3.rs-7372595/v1

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