Article

Germline loss of <i>MBD4</i> predisposes to leukaemia due to a mutagenic cascade driven by 5mC

2017-11-01

Abstract excerpt

Cytosine methylation is essential for normal mammalian development, yet also provides a major mutagenic stimulus. Methylcytosine (5mC) is prone to spontaneous deamination, which introduces cytosine to thymine transition mutations (C>T) upon replication 1 . Cells endure hundreds of 5mC deamination events each day and an intricate repair network is engaged to restrict this damage. Central to this network are the DN...

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Literature Corpus work: bae2989a-9bae-5ceb-b6c9-142cdbd5ffce
DOI: 10.1101/180588

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