Article

R-spondin 3 deletion favors Erk phosphorylation to enhance Wnt signaling and bone formation

2021-09-03

Abstract excerpt

<title>Abstract</title> <p>Activation of Wnt signaling leads to high bone density. The R-spondin family of four secreted glycoproteins (Rspo1-4) amplifies Wnt signaling. In humans, RSPO3 variants are strongly associated with bone density, but how RSPO3 affects skeletal homeostasis is not fully understood. Here we show that in mice Rspo3 haplo-insufficiency or its targeted deletion in osteoprogenitors lead to an i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 69dc9fa0-7127-5322-9843-982cc4925f3e
DOI: 10.21203/rs.3.rs-569623/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

R-spondin 3 deletion favors Erk phosphorylation to enhance Wnt signaling and bone formationDOI 10.21203/rs.3.rs-569623/v2Read

RSPO3 is important for trabecular bone and fracture risk in mice and humans.Semantic proximity Read

The R-spondin family of proteins: emerging regulators of WNT signaling.Semantic proximity Read

Synergistic roles of Wnt modulators R-spondin2 and R-spondin3 in craniofacial morphogenesis and dental development.Semantic proximity Read

RSPO2 as Wnt signaling enabler: Important roles in cancer development and therapeutic opportunitiesSemantic proximity Read

R-Spondin Proteins: A Novel Link to &beta;-catenin ActivationSemantic proximity Read

Class I PI-3-Kinase Signaling Is Critical for Bone Formation Through Regulation of SMAD1 Activity in Osteoblasts.Semantic proximity Read

Loss of signal transducer and activator of transcription 3 impaired the osteogenesis of mesenchymal progenitor cells in vivo and in vitroSemantic proximity Read

Loss of Signal Transducer and Activator of Transcription 3 Impaired the Osteogenesis of Mesenchymal Progenitor Cells in Vivo and in VitroSemantic proximity Read

A conditional allele of Rspo3 reveals redundant function of R-spondins during mouse limb development.Semantic proximity Read

R-spondin2, a novel target of NOBOX: identification of variants in a cohort of women with primary ovarian insufficiency.Semantic proximity Read

A novel function of R-spondin1 in regulating estrogen receptor expression independent of Wnt/β-catenin signalingSemantic proximity Read

The role of R-spondin proteins in cancer biologySemantic proximity Read