Article
RSPO3 is important for trabecular bone and fracture risk in mice and humans.
Nature communications - 13 Aug 2021
Nilsson Karin H, Henning Petra, El Shahawy Maha, Nethander Maria, Andersen Thomas Levin, Ejersted Charlotte, Wu Jianyao, Gustafsson Karin L, Koskela Antti, Tuukkanen Juha, Souza Pedro P C, Tuckermann Jan, Lorentzon Mattias, Ruud Linda Engström, Lehtimäki Terho, Tobias Jon H, Zhou Sirui, Lerner Ulf H, Richards J Brent, Movérare-Skrtic Sofia, Ohlsson Claes
Abstract excerpt
With increasing age of the population, countries across the globe are facing a substantial increase in osteoporotic fractures. Genetic association signals for fractures have been reported at the RSPO3 locus, but the causal gene and the underlying mechanism are unknown. Here we show that the fracture reducing allele at the RSPO3 locus associate with increased RSPO3 expression both at the mRNA and protein levels,...
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