Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A conditional allele of Rspo3 reveals redundant function of R-spondins during mouse limb development.

Genesis (New York, N.Y. : 2000) - 1 Oct 2012

Neufeld Stanley, Rosin Jessica M, Ambasta Anshula, Hui Kristen, Shaneman Venessa, Crowder Ray, Vickerman Lori, Cobb John

Abstract excerpt

R-spondins are secreted ligands that bind cell surface receptors and activate Wnt/β-catenin signaling. Human mutations and gene inactivation studies in mice have revealed a role for these four proteins (RSPO1-4) in diverse developmental processes ranging from sex determination to limb development. Among the genes coding for R-spondins, only inactivation of Rspo3 shows early embryonic lethality (E10.5 in mice)....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Extremities

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Limb Deformities, Congenital

Share to Mice, Transgenic

Share to Thrombospondins

Share to Transcription, Genetic

Source

Identifiers

PMID: 22610508
DOI: 10.1002/dvg.22040

Genes

RSPO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A conditional allele of Rspo3 reveals redundant function of R-spondins during mouse limb development.PMID 22610508Read ↗

Mouse R-spondin2 is required for apical ectodermal ridge maintenance in the hindlimb.Semantic proximity Read ↗

RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6.Semantic proximity Read ↗

Synergistic roles of Wnt modulators R-spondin2 and R-spondin3 in craniofacial morphogenesis and dental development.Semantic proximity Read ↗

The R-spondin family of proteins: emerging regulators of WNT signaling.Semantic proximity Read ↗

R-spondin 3 deletion favors Erk phosphorylation to enhance Wnt signaling and bone formationSemantic proximity Read ↗

The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia.Semantic proximity Read ↗

TALEN-mediated mutagenesis in zebrafish reveals a role for r-spondin 2 in fin ray and vertebral development.Semantic proximity Read ↗

A novel function of R-spondin1 in regulating estrogen receptor expression independent of Wnt/β-catenin signalingSemantic proximity Read ↗

RSPO4 is the major gene in autosomal-recessive anonychia and mutations cluster in the furin-like cysteine-rich domains of the Wnt signaling ligand R-spondin 4.Semantic proximity Read ↗

The role of R-spondin proteins in cancer biologySemantic proximity Read ↗

Mutations in the gene encoding the Wnt-signaling component R-spondin 4 (RSPO4) cause autosomal recessive anonychia.Semantic proximity Read ↗

A new Adamts9 conditional mouse allele identifies its non-redundant role in interdigital web regression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.