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Article

R-spondin2, a novel target of NOBOX: identification of variants in a cohort of women with primary ovarian insufficiency.

Journal of ovarian research - 25 Jul 2017

Bouilly Justine, Beau Isabelle, Barraud Sara, Bernard Valérie, Delemer Brigitte, Young Jacques, Binart Nadine

Abstract excerpt

BACKGROUND: R-spondin2 (Rspo2) is a secreted agonist of the canonical Wnt/β-catenin signaling pathway. Rspo2 plays a key role in development of limbs, lungs and hair follicles, and more recently during ovarian follicle development. Rspo2 heterozygous deficient female mice become infertile around 4 months of age mimicking primary ovarian insufficiency (POI). The study aimed to investigate the regulation of RSPO2...

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Source

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Identifiers

PMID: 28743298
DOI: 10.1186/s13048-017-0345-0
PMCID: PMC5526297

Genes

RSPO2
NOBOX

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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R-spondin2, a novel target of NOBOX: identification of variants in a cohort of women with primary ovarian insufficiency.PMID 28743298Read ↗

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NOBOX is a strong autosomal candidate gene in Tunisian patients with primary ovarian insufficiency.Semantic proximity Read ↗

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