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Article

A novel function of R-spondin1 in regulating estrogen receptor expression independent of Wnt/β-catenin signaling

4 Aug 2020

Abstract excerpt

R-spondin1 (Rspo1) has been featured as a Wnt agonist, serving as a potent niche factor for stem cells in many tissues. Here we unveil a novel role of Rspo1 in promoting estrogen receptor alpha (Esr1) expression, hence regulating the output of steroid hormone signaling in the mouse mammary gland. This action of Rspo1 relies on the receptor Lgr4 and intracellular cAMP-PKA signaling, yet is independent of...

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PMID: 32749219
DOI: 10.7554/elife.56434

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