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Article

Synergistic roles of Wnt modulators R-spondin2 and R-spondin3 in craniofacial morphogenesis and dental development.

Scientific reports - 12 Mar 2021

Alhazmi Nora, Carroll Shannon H, Kawasaki Kenta, Woronowicz Katherine C, Hallett Shawn A, Macias Trevino Claudio, Li Edward B, Baron Roland, Gori Francesca, Yelick Pamela C, Harris Matthew P, Liao Eric C

Abstract excerpt

Wnt signaling plays a critical role in craniofacial patterning, as well as tooth and bone development. Rspo2 and Rspo3 are key regulators of Wnt signaling. However, their coordinated function and relative requirement in craniofacial development and odontogensis are poorly understood. We showed that in zebrafish rspo2 and rspo3 are both expressed in osteoprogenitors in the embryonic craniofacial skeleton. This is...

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Identifiers

PMID: 33712657
DOI: 10.1038/s41598-021-85415-y
PMCID: PMC7954795

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