Article

The role of IL-1 in adipose browning and muscle wasting in CKD-associated cachexia

2021-02-07

Abstract excerpt

<h4>ABSTRACT</h4> Cytokines such as IL-6, TNF-α and IL-1β trigger inflammatory cascades which may play a role in the pathogenesis of chronic kidney disease (CKD)-associated cachexia. CKD was induced by 5/6 nephrectomy in mice. We studied energy homeostasis in Il1β −/− /CKD, Il6 −/− /CKD and Tnfα −/−/ CKD mice and compared with wild type (WT)/CKD controls. Parameters of cachexia phenotype were completely normal...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 69cf3726-8612-5d2e-90cd-66cd2af327fc
DOI: 10.1101/2021.02.05.429984

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The role of IL-1 in adipose browning and muscle wasting in CKD-associated cachexiaDOI 10.1101/2021.02.05.429984Read

The role of IL-1 in adipose browning and muscle wasting in CKD-associated cachexiaSemantic proximity Read

Targeting interleukin-1 for reversing fat browning and muscle wasting in infantile nephropathic cystinosisSemantic proximity Read

Obesity-Related Kidney Disease: A Growing Threat to Renal HealthSemantic proximity Read

Transcriptomic Suppression of Immune and Regenerative Signalling in Skeletal Muscle of Patients with Chronic Kidney DiseaseSemantic proximity Read

Time-Restricted Feeding Attenuates Kidney Damage and Preserves Renal Function in Mouse Model of Chronic Kidney DiseaseSemantic proximity Read

Loss of the alternative calcineurin variant CnAβ1 enhances brown adipocyte differentiation and drives metabolic overactivation through FoxO1 activationSemantic proximity Read

Synergic Renoprotective Effects Of Combined ASC Therapy With RAAS Blockade In Experimental Advanced CKDSemantic proximity Read

Chronic kidney disease exacerbates hyperlipidemia and atherosclerosis via miR-148a-3p targeting SIK1/AMPKα1 in liverSemantic proximity Read

Increased severity of chronic kidney disease in response to high potassium intake is dependent on mineralocorticoid receptor activationSemantic proximity Read

Genetic susceptibility and loss of Nr4a1 enhances macrophage-mediated renal injury in CKD.Semantic proximity Read

Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasisSemantic proximity Read

Inflammation-mediated Upregulation of VCAM-1 but not KIM-1 during Acute Kidney Injury to Chronic Kidney Disease TransitionSemantic proximity Read