Article

Loss of the alternative calcineurin variant CnAβ1 enhances brown adipocyte differentiation and drives metabolic overactivation through FoxO1 activation

2025-05-11

Abstract excerpt

<h4>ABSTRACT</h4> The alternative calcineurin A variant CnAβ1 has a unique C-terminal domain that provides it with distinct subcellular localization and mechanism of action different from other calcineurin isoforms. Here, we used mice lacking CnAβ1’s C-terminal domain (CnAβ1 Δi12 ) to show that the absence of this specific isoform strongly reprograms metabolism. CnAβ1 Δi12 mice on a high-fat diet showed reduced...

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Literature Corpus work: 664d5faa-feb4-5d53-85c8-25872fb912e0
DOI: 10.1101/2025.05.09.653054

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Loss of the alternative calcineurin variant CnAβ1 enhances brown adipocyte differentiation and drives metabolic overactivation through FoxO1 activationDOI 10.1101/2025.05.09.653054Read

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