Transcriptomic Suppression of Immune and Regenerative Signalling in Skeletal Muscle of Patients with Chronic Kidney Disease

Abstract excerpt

<h4>Background</h4> Chronic kidney disease (CKD) is a growing public health emergency with a global prevalence of approximately 14%. Sarcopenia is a common complication of CKD contributing to functional decline and poor outcomes. However, the molecular mechanisms driving muscle wasting in CKD remain incompletely understood. This study aimed to characterise the transcriptomic profile in individuals with CKD compar...

Topics

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• Cardiovascular Disease and Adiposity
• Diet and metabolism studies
• Extracellular vesicles in disease
• Gut microbiota and health
• IL-33, ST2, and ILC Pathways
• Muscle metabolism and nutrition
• Single-cell and spatial transcriptomics
• Tissue Engineering and Regenerative Medicine

Identifiers and source

Literature Corpus work

efbbbeab-18e5-536c-974e-3dc74cbd9522

DOI

10.1101/2025.07.11.664285