Article

Targeting interleukin-1 for reversing fat browning and muscle wasting in infantile nephropathic cystinosis

2021-02-07

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Ctns −/− mice, a mouse model of infantile nephropathic cystinosis, exhibit hypermetabolism with adipose tissue browning and profound muscle wasting. Inflammatory cytokines such as IL-1 trigger inflammatory cascades and play an important role in the pathogenesis of cachexia. Anakinra is an FDA-approved IL-1 receptor antagonist that blocks IL-1 signaling and may provide target...

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Literature Corpus work: 2617ecac-a979-5d13-856d-c8e7af964c53
DOI: 10.1101/2021.02.05.429989

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