Back to search

Article

The role of IL-1 in adipose browning and muscle wasting in CKD-associated cachexia

2021-02-18

Abstract excerpt

Cytokines such as IL-6, TNF-α and IL-1β trigger inflammatory cascades which may play a role in the pathogenesis of chronic kidney disease (CKD)-associated cachexia. CKD was induced by 5/6 nephrectomy in mice. We studied energy homeostasis in Il1β −/− /CKD, Il6 −/− / CKD and Tnf α −/− / CKD mice and compared with wild type (WT)/CKD controls. Parameters of cachexia phenotype were completely normalized in Il1β −/− /C...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
03acb6a1-1ad7-568c-985d-a2df1751063f
DOI
10.21203/rs.3.rs-156249/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The role of IL-1 in adipose browning and muscle wasting in CKD-associated cachexiaDOI 10.21203/rs.3.rs-156249/v1
The role of IL-1 in adipose browning and muscle wasting in CKD-associated cachexiaSemantic proximity
Targeting interleukin-1 for reversing fat browning and muscle wasting in infantile nephropathic cystinosisSemantic proximity
Obesity-Related Kidney Disease: A Growing Threat to Renal HealthSemantic proximity
Transcriptomic Suppression of Immune and Regenerative Signalling in Skeletal Muscle of Patients with Chronic Kidney DiseaseSemantic proximity
Loss of the alternative calcineurin variant CnAβ1 enhances brown adipocyte differentiation and drives metabolic overactivation through FoxO1 activationSemantic proximity
JAK1/2 Inhibition Delays Cachexia and Improves Survival through Increased Food IntakeSemantic proximity
Synergic Renoprotective Effects Of Combined ASC Therapy With RAAS Blockade In Experimental Advanced CKDSemantic proximity
Exploring the role of chemerin in skeletal muscle phenotype in those with kidney disease.Semantic proximity
Chronic kidney disease and high eGFR according to body composition phenotype in adults with normal BMI.Semantic proximity
Obesity-related kidney disease.Semantic proximity
Chronic kidney disease exacerbates hyperlipidemia and atherosclerosis via miR-148a-3p targeting SIK1/AMPKα1 in liverSemantic proximity
miR-26a Limits Muscle Wasting and Cardiac Fibrosis through Exosome-Mediated microRNA Transfer in Chronic Kidney DiseaseSemantic proximity
Select a neighboring publication to make it the new centre.