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Chronic kidney disease exacerbates hyperlipidemia and atherosclerosis via miR-148a-3p targeting SIK1/AMPKα1 in liver

2025-10-10

Abstract excerpt

<h4>Background</h4> Cardiovascular complications are the leading cause of death in patients with chronic kidney disease (CKD). As a major risk factor for atherosclerotic cardiovascular disease (ASCVD), hyperlipidemia is a common sequela of CKD, which is linked to increased lipid synthesis, impaired lipoprotein clearance, and maladapted reverse cholesterol transport. Because exosomes can transport miRNAs to modula...

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Literature Corpus work
36f92b22-8cf9-5d0f-b3ca-0df90f4db577
DOI
10.1101/2025.10.08.681287
Open publication

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Chronic kidney disease exacerbates hyperlipidemia and atherosclerosis via miR-148a-3p targeting SIK1/AMPKα1 in liverDOI 10.1101/2025.10.08.681287
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