Article

The frequency and fitness of m6A-associated variants may be modulated by thermodynamic stability of the overlapping G-quadruplex

2022-06-15

Abstract excerpt

<h4>Background: </h4> Post-transcriptional modifications like m6A, and secondary structures like G-quadruplex (G4), play an important role in RNA processing. Despite an emerging number of studies focusing on m6A and G4 separately, there are less studies about their synergy. Since m6A is known to be enzymatically created in DRACH-motif, and genetic variants may create a novel DRACH-motif or abolish a pre-existing D...

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Literature Corpus work: 69b9b725-5aaa-50aa-ac07-e1527ea5eb77
DOI: 10.21203/rs.3.rs-1737671/v1

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