Article

Genetic variations in G-Quadruplex forming sequences affect the transcription of human disease-related genes

2022-08-16

Abstract excerpt

<h4>ABSTRACT</h4> Guanine-rich DNA strands can fold into non-canonical four-stranded secondary structures named G-quadruplexes (G4s). G4s folded in proximal promoter regions (PPR) are associated either with positive or negative transcriptional regulation. Given that single nucleotide variants (SNVs) affecting G4 folding (G4-Vars) may alter gene transcription, and that SNVs are associated with the human diseases’...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 707fd141-e7c2-5767-9250-ff9f724e4994
DOI: 10.1101/2022.08.16.503999

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic variations in G-Quadruplex forming sequences affect the transcription of human disease-related genesDOI 10.1101/2022.08.16.503999Read

Genetic variations in G-quadruplex forming sequences affect the transcription of human disease-related genes.Semantic proximity Read

G-quadruplex structural variations in human genome associated with single-nucleotide variations and their impact on gene activity.Semantic proximity Read

Analysis of Nucleotide Variations in Human G-Quadruplex Forming Regions Associated with Disease States.Semantic proximity Read

Analysis of nucleotide variations in human g-quadruplex forming regions associated with disease statesSemantic proximity Read

G-quadruplexes as pivotal components of <i>cis</i> -regulatory elements in the human genomeSemantic proximity Read

Integrative analysis reveals RNA G-Quadruplexes in UTRs are selectively constrained and enriched for functional associationsSemantic proximity Read

Pathogenic SNPs Affect Both RNA and DNA G-Quadruplexes' Responses to Ligands.Semantic proximity Read

A Mammalian Genomic Signature Shaped by Single Nucleotide Variants Regulates Transcriptome Integrity and DiversitySemantic proximity Read

Thermodynamic stability of G-quadruplex and overlapping m6A: Position-dependent collaborators in allele frequency and fitness?Semantic proximity Read

Variation and selection at predicted G-quadruplexes across the human pangenomeSemantic proximity Read

The Impact of Non-coding G-quadruplex Variants on Human Traits and Disease SusceptibilitySemantic proximity Read

SNPs associated with Metabolic Disorders Disrupt Structural Properties of DNA G-Quadruplexes in Regulatory Regions relevant during Tumor DevelopmentSemantic proximity Read