Article

Thermodynamic stability of G-quadruplex and overlapping m6A: Position-dependent collaborators in allele frequency and fitness?

2021-04-29

Abstract excerpt

<h4>Background</h4> Post-transcriptional modifications like m6A, and secondary structures like G-quadruplex (G4), play an important role in RNA processing. Despite an emerging number of studies focusing on m6A and G4 separately, there are less studies about their synergy. <h4>Aim</h4> Since m6A is known to be enzymatically created in DRACH-motif, and genetic variants may create a novel DRACH-motif or abolish a p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 929e48b2-25fc-52e9-9a24-3035819f6a95
DOI: 10.1101/2021.04.28.441767

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Thermodynamic stability of G-quadruplex and overlapping m6A: Position-dependent collaborators in allele frequency and fitness?DOI 10.1101/2021.04.28.441767Read

The frequency and fitness of m6A-associated variants may be modulated by thermodynamic stability of the overlapping G-quadruplexSemantic proximity Read

G-quadruplex structural variations in human genome associated with single-nucleotide variations and their impact on gene activity.Semantic proximity Read

Analysis of Nucleotide Variations in Human G-Quadruplex Forming Regions Associated with Disease States.Semantic proximity Read

G-quadruplexes as pivotal components of <i>cis</i> -regulatory elements in the human genomeSemantic proximity Read

Variation and selection at predicted G-quadruplexes across the human pangenomeSemantic proximity Read

Alternative splicing modulation by G-quadruplexesSemantic proximity Read

Analysis of nucleotide variations in human g-quadruplex forming regions associated with disease statesSemantic proximity Read

Genetic variations in G-Quadruplex forming sequences affect the transcription of human disease-related genesSemantic proximity Read

Genetic variations in G-quadruplex forming sequences affect the transcription of human disease-related genes.Semantic proximity Read

G-Quadruplex-Protein Interactome at Human Gene PromotersSemantic proximity Read

Profiling human pathogenic repeat expansion regions by synergistic and multi-level impacts on molecular connectionsSemantic proximity Read

A Mammalian Genomic Signature Shaped by Single Nucleotide Variants Regulates Transcriptome Integrity and DiversitySemantic proximity Read