Article

Variation and selection at predicted G-quadruplexes across the human pangenome

2026-06-23

Abstract excerpt

<h4>ABSTRACT</h4> G-quadruplexes (G4s), non-canonical DNA structures whose sequence motifs occupy approximately 1% of the human genome, are important for myriad cellular functions, including regulating transcription and replication. Yet they also contribute to genomic instability by increasing mutations and structural variation. Despite their significance, G4 motifs have not been studied in detail across multiple...

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Literature Corpus work: df8b25d6-9086-51de-8755-e4ee438fe9c3
DOI: 10.64898/2026.06.18.733261

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