Article

Analysis of nucleotide variations in human g-quadruplex forming regions associated with disease states

2023-02-02

Abstract excerpt

<h4>ABSTRACT</h4> While the role of G4 G quadruplex structures has been identified in cancers and metabolic disorders, single nucleotide variations (SNVs) and their effect on G4s in disease contexts have not been extensively studied. The COSMIC and CLINVAR databases were used to detect SNVs present in G4s to identify sequence level changes and their effect on alteration of G4 secondary structure. 37,515 G4 SNVs i...

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Literature Corpus work: 8d1f9756-fe4b-5371-9a05-fed096b1b56b
DOI: 10.1101/2023.01.30.526341

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