Analysis of Nucleotide Variations in Human G-Quadruplex Forming Regions Associated with Disease States.

Abstract excerpt

While the role of G quadruplex (G4) structures has been identified in cancers and metabolic disorders, single nucleotide variations (SNVs) and their effect on G4s in disease contexts have not been extensively studied. The COSMIC and CLINVAR databases were used to detect SNVs present in G4s to identify sequence level changes and their effect on the alteration of the G4 secondary structure. A total of 37,515 G4...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to G-Quadruplexes
• Share to Mutation
• Share to Nucleotides