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Article

Metabolic disease variants rewire gene regulation through disruption of DNA G-quadruplex structures.

Genome biology - 10 Jun 2026

Lahnsteiner Angelika, Ellmer Victoria, Schönauer Esther, Huber Julia, Lexa Matej, Wiederstein Markus, Risch Angela

Abstract excerpt

BACKGROUND: The global prevalence of metabolic diseases (MetDs) continues to rise and is associated with an increased cancer risk. Genome-wide association studies have identified numerous single nucleotide variants (SNVs) linked to MetDs, some within genes also implicated in tumorigenesis. G-quadruplexes (G4s) are non-canonical DNA secondary structures that regulate gene expression in diverse and context...

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Share to DNA
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Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Share to Promoter Regions, Genetic

Source

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Identifiers

PMID: 42271430
DOI: 10.1186/s13059-026-04147-2
PMCID: PMC13479703

Genes

MICB
PLA2G6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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