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Hepatocellular carcinoma-associated <i>AXIN1</i> mutations drive low levels of Wnt/β-catenin pathway activity that allow for niche-independent growth and YAP/TAZ signaling

2024-12-03

Abstract excerpt

In healthy cells, AXIN1 organizes assembly of a large destruction complex that mediates proteolysis of the transcriptional co-activator β-catenin to prevent inappropriate Wnt/β-catenin pathway activation. In hepatocellular carcinoma (HCC), AXIN1 mutations (11%) associate with a poor-prognosis subtype that is molecularly distinct from β-catenin-mutant HCC (28-40%). How AXIN1 deficiency drives HCC formation has re...

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Literature Corpus work
1fe53f7a-e7cb-546c-8f0b-0cb71cb6e382
DOI
10.1101/2024.11.28.625941
Open publication

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Hepatocellular carcinoma-associated <i>AXIN1</i> mutations drive low levels of Wnt/β-catenin pathway activity that allow for niche-independent growth and YAP/TAZ signalingDOI 10.1101/2024.11.28.625941
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