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New three-dimensional preclinical models to understand and treat liver cancers activated for the β-catenin pathway

2026-04-03

Abstract excerpt

<h4>Background & aims</h4> Constitutive activation of the β-catenin pathway is a determining feature in the pathogenesis of two primary liver cancers, namely HCC and hepatoblastoma (HB). Activating alterations in CTNNB1 gene and, to a lesser extent, inhibiting alterations in APC gene are observed in 30 to 40% of HCC cases and 80 to 90% of HB cases. For both tumours, therapeutic management is far from optimal. T...

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Literature Corpus work
b2134cb2-9683-5ad7-b3b3-95a93481e7e3
DOI
10.64898/2026.04.01.715868
Open publication

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