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Article

AXIN deficiency in human and mouse hepatocytes induces hepatocellular carcinoma in the absence of β-catenin activation.

Journal of hepatology - 1 Jun 2018

Abitbol Shirley, Dahmani Rajae, Coulouarn Cédric, Ragazzon Bruno, Mlecnik Bernhard, Senni Nadia, Savall Mathilde, Bossard Pascale, Sohier Pierre, Drouet Valerie, Tournier Emilie, Dumont Florent, Sanson Romain, Calderaro Julien, Zucman-Rossi Jessica, Vasseur-Cognet Mireille, Just Pierre-Alexandre, Terris Benoît, Perret Christine, Gilgenkrantz Hélène

Abstract excerpt

BACKGROUND & AIMS: The Wnt/β-catenin pathway is the most frequently deregulated pathway in hepatocellular carcinoma (HCC). Inactivating mutations of the gene encoding AXIN1, a known negative regulator of the Wnt/β-catenin signaling pathway, are observed in about 10% of HCCs. Whole-genome studies usually place HCC with AXIN1 mutations and CTNNB1 mutations in the group of tumors with Wnt/β-catenin activated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Carcinoma, Hepatocellular

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Source

Identifiers

PMID: 29525529
DOI: 10.1016/j.jhep.2017.12.018

Genes

AXIN1
CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

AXIN deficiency in human and mouse hepatocytes induces hepatocellular carcinoma in the absence of β-catenin activation.PMID 29525529Read ↗

Conditional disruption of Axin1 leads to development of liver tumors in mice.Semantic proximity Read ↗

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Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas.Semantic proximity Read ↗

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AXIN1 Mutated Hepatocellular Carcinoma.Semantic proximity Read ↗

Genetic alterations of Wnt signaling pathway–associated genes in hepatocellular carcinomaSemantic proximity Read ↗

Mutations of beta-catenin and AXIN I genes are a late event in human hepatocellular carcinogenesis.Semantic proximity Read ↗

AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1.Semantic proximity Read ↗

Deleting the β-catenin degradation domain in mouse hepatocytes drives hepatocellular carcinoma or hepatoblastoma-like tumor growth.Semantic proximity Read ↗

Notch activity characterizes a common hepatocellular carcinoma subtype with unique molecular and clinicopathologic features.Semantic proximity Read ↗

WNT/β-catenin signaling in the development of liver cancers.Semantic proximity Read ↗

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