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Subcellular spatial transcriptomics reveals immune–stromal crosstalk within the synovium of patients with juvenile idiopathic arthritis

2025-08-08

Abstract excerpt

Juvenile idiopathic arthritis (JIA) is the most prevalent chronic inflammatory arthritis of childhood, yet the spatial organization in the synovium remains poorly understood. Here, we perform subcellular-resolution spatial transcriptomic profiling of synovial tissue from patients with active JIA. We identify diverse immune and stromal cell populations and reconstruct spatially defined cellular niches. Applying a n...

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Identifiers and source

Literature Corpus work
69a09a0f-e698-5ef9-a2a1-1ef7c155d13d
DOI
10.1101/2025.08.05.25332835
Open publication

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Subcellular spatial transcriptomics reveals immune–stromal crosstalk within the synovium of patients with juvenile idiopathic arthritisDOI 10.1101/2025.08.05.25332835
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