Article

A novel innate lymphoid cell delineates childhood autoimmune arthritis

2018-09-13

Abstract excerpt

Inflammation in autoimmune disease is mediated by a complex network of interacting cells. Their identity and cross-talk are encoded in messenger RNA (mRNA). Juvenile idiopathic arthritis (JIA), a chronic autoimmune arthritis of childhood, is characterised by synovial inflammation with infiltration of both innate and adaptive immune cells 1 . Activated T cells play a role in disease 2 but the cell types that driv...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ebf736d4-46bc-5e90-9cc2-ac429a4adb15
DOI: 10.1101/416784

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A novel innate lymphoid cell delineates childhood autoimmune arthritisDOI 10.1101/416784Read

Generation of a T cell receptor, cytokine and cell repertoire synovial fluid atlas to define commonalities and dissimilarities between arthritic diseases through systems immunology approachesSemantic proximity Read

Unraveling immune cell heterogeneity in autoimmune arthritis: insights from single-cell RNA sequencingSemantic proximity Read

Synovial tissue atlas in juvenile idiopathic arthritis reveals pathogenic niches associated with disease severitySemantic proximity Read

Immune Cell-Related Genes in Juvenile Idiopathic Arthritis Identified Using Transcriptomic and Single-Cell Sequencing DataSemantic proximity Read

Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes.Semantic proximity Read

Defining Inflammatory Cell States in Rheumatoid Arthritis Joint Synovial Tissues by Integrating Single-cell Transcriptomics and Mass CytometrySemantic proximity Read

Large-scale integrative analysis of juvenile idiopathic arthritis for new insight into its pathogenesis.Semantic proximity Read

Large-scale Integrative Analysis of Juvenile Idiopathic Arthritis for New Insight into Its PathogenesisSemantic proximity Read

Antigen-driven PD-1 <sup>+</sup> <i>TOX</i> <sup>+</sup> <i>EOMES</i> <sup>+</sup> and PD-1 <sup>+</sup> <i>TOX</i> <sup>+</sup> <i>BHLHE40</i> <sup>+</sup> synovial T lymphocytes regulate chronic inflammation <i>in situ</i>Semantic proximity Read

Coordinated immune dysregulation in Juvenile Dermatomyositis revealed by single-cell genomicsSemantic proximity Read

Population-level single-cell genomics reveals conserved gene programs in systemic juvenile idiopathic arthritisSemantic proximity Read

Integrated single-cell transcriptomics and epigenomics reveals strong germinal center-associated etiology of autoimmune risk lociSemantic proximity Read