Article
Three-dimensional spatial transcriptomics uncovers cell type localizations in the human rheumatoid arthritis synovium
11 Feb 2022
Abstract excerpt
The inflamed rheumatic joint is a highly heterogeneous and complex tissue with dynamic recruitment and expansion of multiple cell types that interact in multifaceted ways within a localized area. Rheumatoid arthritis synovium has primarily been studied either by immunostaining or by molecular profiling after tissue homogenization. Here, we use Spatial Transcriptomics, where tissue-resident RNA is spatially...
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