Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Resolving microenvironment complexity and cellular heterogeneity in osteoarthritis via spatial transcriptomics

15 Jul 2025

Abstract excerpt

Osteoarthritis (OA) is a multifactorial joint disease characterized by complex tissue interactions, spatially compartmentalized pathology, and diverse cellular phenotypes. Traditional transcriptomic approaches have provided valuable insights into OA pathogenesis but lack the spatial resolution required to understand how cellular behaviour is influenced by local tissue context. Spatial transcriptomics (ST) has...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules Research
Share to Immune cells in cancer
Share to Osteoarthritis Treatment and Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40669534
DOI: 10.1016/j.joca.2025.07.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Resolving microenvironment complexity and cellular heterogeneity in osteoarthritis via spatial transcriptomicsPMID 40669534Read ↗

Three-dimensional spatial transcriptomics uncovers cell type localizations in the human rheumatoid arthritis synoviumSemantic proximity Read ↗

Spatial analysis of the osteoarthritis microenvironment: techniques, insights, and applications.Semantic proximity Read ↗

Spatial transcriptomics in autoimmune rheumatic disease: potential clinical applications and perspectivesSemantic proximity Read ↗

Spatial transcriptomics reveals distinct inflammatory and adaptive immune properties of rheumatoid arthritis synovial fibroblastsSemantic proximity Read ↗

Exploring inflammatory signatures in arthritic joint biopsies with Spatial TranscriptomicsSemantic proximity Read ↗

New Developments in Transcriptomic Analysis of Synovial TissueSemantic proximity Read ↗

Molecular and spatial profiling identifies immune endotypes for the stratification of OA patientsSemantic proximity Read ↗

Spatiotemperal Dynamics of Osteoarthritis: Bridging Insights from Bench to Bedside.Semantic proximity Read ↗

Spatial Transcriptomic Technologies.Semantic proximity Read ↗

Integrative Spatial Proteomics and Single-Cell RNA Sequencing Unveil Molecular Complexity in Rheumatoid Arthritis for Novel Therapeutic TargetingSemantic proximity Read ↗

Synovial transcriptional clusters link cartilage degeneration to cell-type-specific gene expression in knee osteoarthritisSemantic proximity Read ↗

Subcellular spatial transcriptomics reveals immune–stromal crosstalk within the synovium of patients with juvenile idiopathic arthritisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.