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Article

Juvenile idiopathic arthritis-associated genetic loci exhibit spatially constrained gene regulatory effects across multiple tissues and immune cell types.

Journal of autoimmunity - 1 Jul 2023

Pudjihartono N, Ho D, Golovina E, Fadason T, Kempa-Liehr A W, O'Sullivan J M

Abstract excerpt

Juvenile idiopathic arthritis (JIA) is an autoimmune, inflammatory joint disease with complex genetic etiology. Previous GWAS have found many genetic loci associated with JIA. However, the biological mechanism behind JIA remains unknown mainly because most risk loci are located in non-coding genetic regions. Interestingly, increasing evidence has found that regulatory elements in the non-coding regions can...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37229810
DOI: 10.1016/j.jaut.2023.103046

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