Article

Spatial transcriptomics reveals distinct inflammatory and adaptive immune properties of rheumatoid arthritis synovial fibroblasts

2025-11-10

Abstract excerpt

<h4>Objective</h4> Rheumatoid arthritis (RA) synovium displays cellular heterogeneity, with gene expression driving pathogenesis. Prior transcriptomic studies relied on disaggregated tissue, which causes cell loss and induction. We applied spatial transcriptomics to investigate synovial lining and sublining fibroblasts and macrophages from RA and osteoarthritis (OA) patients. <h4>Methods</h4> Fresh frozen synovi...

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Literature Corpus work: 3b57635b-cabe-56ff-b4f8-4e16dffd8a74
DOI: 10.1101/2025.11.08.687060

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