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Synovial tissue atlas in juvenile idiopathic arthritis reveals pathogenic niches associated with disease severity

2 Jul 2025

Abstract excerpt

Precision application of targeted therapies is urgently needed to improve long-term clinical outcomes for children affected by inflammatory arthritis, known as juvenile idiopathic arthritis (JIA). Progress has been hampered by our limited understanding of the cellular basis of inflammation in the target tissue of the disease, the synovial membrane. Here, we analyzed biopsies from the inflamed joints of...

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PMID: 40601776
DOI: 10.1126/scitranslmed.adt6050

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