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Mitochondrial cardiolipin sequestration of caspofungin underlies <i>Cryptococcus neoformans</i> inherent resistance and may contribute to cardiotoxicity

2026-01-20

Abstract excerpt

Cryptococcus exhibits inherent resistance to the echinocandin, caspofungin, which inhibits the synthesis of (1,3)-β-D-glucan, a key component of the polysaccharide cell wall. The essential FKS1 gene encodes the catalytic subunit of (1,3)-β-D-glucan synthase and caspofungin effectively inhibits its activity in vitro, yet the drug remains ineffective against Cryptococcus, suggesting mechanisms beyond target insens...

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Literature Corpus work
69919af5-4456-5160-98ff-692eb5899e77
DOI
10.64898/2026.01.20.700633
Open publication

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