Article

Multifactorial role of mitochondria in echinocandin tolerance revealed by transcriptome analysis of drug-tolerant cells

2021-07-08

Abstract excerpt

Fungal infections cause significant mortality and morbidity worldwide, and the limited existing antifungal reservoir is further weakened by the emergence of strains resistant to echinocandins, a first line of antifungal therapy. Candida glabrata is an opportunistic fungal pathogen that rapidly develops mutations in the echinocandin drug target, β-1,3-glucan synthase (GS), which are associated with drug resistance...

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Literature Corpus work: 55f67516-dcc1-52d6-a44e-ceeb78b3612f
DOI: 10.1101/2021.07.07.451565

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