Article

Evaluation of protein kinase D auto-phosphorylation as biomarker for NLRP3 inflammasome activation

2021-03-04

Abstract excerpt

<h4>Background</h4> The NLRP3 inflammasome is a critical component of sterile inflammation, which is involved in many diseases. However, there is currently no known proximal biomarker for measuring NLRP3 activation in pathological conditions. Protein kinase D (PKD) has emerged as an important NLRP3 kinase that catalyzes the release of a phosphorylated NLRP3 species that is competent for inflammasome complex assem...

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Literature Corpus work: 698b8d67-242b-5e3f-b385-2cbb6d5b078b
DOI: 10.1101/2021.03.04.433858

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