Article
A patent review of NLRP3 inhibitors to treat autoimmune diseases
3 Jun 2023
Abstract excerpt
INTRODUCTION: NOD-like receptor family pyrin domain containing 3 (NLRP3) can sense a plethora of exogenous and endogenous dangers. Upon activation, a multimeric protein complex, the NLRP3 inflammasome, is formed to initiate the innate immune responses. Emerging studies have implicated the pathophysiological roles of this protein complex in human disorders, highlighting that it represents a druggable target for...
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