Back to search

Article

Human NLRP1 and NLRP3 interact to drive inflammation in inflammosomopathies and inflammatory diseases

2026-01-29

Abstract excerpt

Inflammasomes are multiprotein complexes that form and activate after exposure to pathogenic microbes and host danger signals that trigger an inflammatory response. Although NLRP1 and NLRP3 inflammasomes share structural similarities and can be activated by similar stimuli, no evidence of heterotypic inflammasome assemblies has been reported. Here, we identify a unique interaction between NLRP1 and NLRP3 in human...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
81b6dbf0-1ccf-58bd-a54f-9de6e083b366
DOI
10.64898/2026.01.26.701718
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Human NLRP1 and NLRP3 interact to drive inflammation in inflammosomopathies and inflammatory diseasesDOI 10.64898/2026.01.26.701718
Human NLRP1: From the shadows to center stageSemantic proximity
A detailed Molecular Network Map and Model of the NLRP3 InflammasomeSemantic proximity
NLRP3 inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases.Semantic proximity
The Role of NLR-related Protein 3 Inflammasome in Host Defense and Inflammatory DiseasesSemantic proximity
NLRP3 Inflammasome and Inflammatory DiseasesSemantic proximity
A patent review of NLRP3 inhibitors to treat autoimmune diseasesSemantic proximity
Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectivesSemantic proximity
Differential role of the NLRP 3 inflammasome in infection and tumorigenesisSemantic proximity
Posttranslational modifications of NLRP3 and their regulatory roles in inflammasome activationSemantic proximity
To protect or adversely affect? The dichotomous role of the NLRP1 inflammasome in human diseaseSemantic proximity
[Inflammasome and interleukin 1].Semantic proximity
The NLRP1 inflammasome: new mechanistic insights and unresolved mysteriesSemantic proximity
Select a neighboring publication to make it the new centre.