Article
[Regulation of the NLRP3 inflammasome].
Medecine sciences : M/S - 1 Jan 2018
Groslambert Marine, Py Bénédicte F
Abstract excerpt
The innate immunity constitutes an efficient barrier by rapidly detecting pathogens and tissue damages through pattern recognition receptors including NLRP3. Moreover, inappropriate NLRP3 activation causes deleterious inflammation and contributes to various conditions including atherosclerosis, diabetes, gout and Alzheimer's diseases. NLRP3 assembles a multimeric inflammasome complex serving as an activation...
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