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Article

CRISPR-Based Screen Links an Inhibitor of Nonsense-Mediated Decay to eIF4A3 Target Engagement.

ACS chemical biology - 19 Jun 2020

Cencic Regina, Naineni Sai Kiran, Pugsley Lauren, Senéchal Patrick, Sahni Ananya, Pelletier Jerry

Abstract excerpt

Eukaryotic initiation factor (eIF) 4A3 is a DEAD-box RNA helicase and a core component of the exon-junction complex (EJC). The EJC marks the location of exon:exon junctions following the removal of introns by splicing and plays a critical role in an mRNA surveillance program known as nonsense-mediated decay (NMD). NMD is often triggered by the presence of a premature termination codon (PTC) upstream of the EJC,...

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PMID: 32401488
DOI: 10.1021/acschembio.0c00253

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