Article

Expansion of human hematopoietic stem cells by inhibiting translation

2023-11-29

Abstract excerpt

Hematopoietic stem cell (HSC) transplantation using umbilical cord blood (UCB) is a potentially life-saving treatment for leukemia and bone marrow failure but is limited by the low number of HSCs in UCB. The loss of HSCs after ex vivo manipulation is also a major obstacle to gene editing for inherited blood disorders. HSCs require a low rate of translation to maintain their capacity for self-renewal, but hematopoi...

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Literature Corpus work: 0b01491e-be04-5557-ab3b-a898898fd78b
DOI: 10.1101/2023.11.28.568925

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