Sex-specific effects of SNAP-25 genotype on verbal memory and Alzheimer's disease biomarkers in clinically normal older adults.

doi:10.1002/alz.12989

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Sex-specific effects of SNAP-25 genotype on verbal memory and Alzheimer's disease biomarkers in clinically normal older adults.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Aug 2023

Saloner Rowan, Paolillo Emily W, Wojta Kevin J, Fonseca Corrina, Gontrum Eva Q, Lario-Lago Argentina, Rabinovici Gil D, Yokoyama Jennifer S, Rexach Jessica E, Kramer Joel H, Casaletto Kaitlin B

Abstract excerpt

INTRODUCTION: We tested sex-dependent associations of variation in the SNAP-25 gene, which encodes a presynaptic protein involved in hippocampal plasticity and memory, on cognitive and Alzheimer's disease (AD) neuroimaging outcomes in clinically normal adults. METHODS: Participants were genotyped for SNAP-25 rs1051312 (T > C; SNAP-25 expression: C-allele > T/T). In a discovery cohort (N = 311), we tested the sex...

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PMID: 36807763
DOI: 10.1002/alz.12989
PMCID: PMC10435666

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